Delayed-type hypersensitivity reaction to ethambutol and isoniazid

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Delayed-type hypersensitivity reaction to ethambutol and isoniazid.

A 24-year-old woman had recently started antitubercular therapy with isoniazid, ethambutol and rifampicin. This therapy was discontinued 2 weeks later due to an itchy, desquamative, erythematous, papular rash, with painful crusts and excoriations, spreading from the face and hands to the rest of the body. 5 days after withdrawal of all drugs, widespread desquamation and exfoliation with predile...

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Hypersensitivity Reaction and Tolerance Induction to Ethambutol

Tuberculosis remains the leading cause of death worldwide from any infectious agent and the alarming increase in the annual incidence of new cases has been described as a global emergency. Mycobacterium infection requires simultaneous administration of multiple drugs. Although the majority of treatment courses progress with minor side effects, adverse reactions to antituberculosis drugs occur i...

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Serious delayed hypersensitivity reaction to oxaliplatin.

With great interest we read the articles of Siu et al. [1] and Maindrault-Goebel et al. [2]. Both report on immediate type hypersensitivity reactions to oxaliplatin, occurring in about 10–15% of patients, mostly after several courses of therapy. We recently observed a quite different presentation of hypersensitivity to oxaliplatin, consisting of severe respiratory symptoms about 24 h after the ...

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Role of IL-16 in delayed-type hypersensitivity reaction.

Interleukin (IL)-16 is a chemoattractant cytokine for CD4(+) leukocytes. Because delayed-type hypersensitivity (DTH) reaction is mediated by T helper 1 (Th1) cells and CD4(+) T cells can be chemoattracted by IL-16, we have investigated the involvement of IL-16 in the DTH reaction. Immunohistochemical analysis revealed the IL-16 expression in infiltrating cells and epithelial cells in the DTH fo...

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Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

Background We experienced a rare case of immediate type hypersensitivity and late phase reaction to anti-tubercular therapy consisting of ethambutol and levofloxacin, which occurred in close succession, giving the appearance of a single, continuous reaction to one drug. Case presentation The patient was a man in his 70's who began therapy consisting of isoniazide, rifampicin, and ethambutol f...

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ژورنال

عنوان ژورنال: Contact Dermatitis

سال: 2002

ISSN: 0105-1873

DOI: 10.1034/j.1600-0536.2002.460610.x